To understand a biological system, knowing protein identity, modifications, and relative abundance are often just the beginning. Augmenting this information with an assessment of protein structure can provide the keys to understanding protein function.
While not an all-inclusive list, several of the most common study types are listed below.
Identification of disulfide bonds
Using a combination of fragmentation techniques, we are able to map which cysteines in a protein share a disulfide bond.
Numerous MS-compatible cross-linkers are available to assist in determining contact sites between residues within a single or among multiple proteins.
Hydrogen-deuterium exchange mass spectrometry can provide a view of the conformation and dynamics of proteins. As of May 1, 2018 we do not yet have these workflows in place, but are looking to add them within the next year. If you are interested in H-D Exchange, please let us know!!