To understand a biological system, knowing protein identity, modifications, and relative abundance are often just the beginning. Augmenting this information with an assessment of protein structure can provide the keys to understanding protein function.

While not an all-inclusive list, several of the most common study types are listed below.

Identification of disulfide bonds

 

Using a combination of fragmentation techniques, we are able to map which cysteines in a protein share a disulfide bond.


Cross-Linked Peptides

 

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Numerous MS-compatible cross-linkers are available to assist in determining contact sites between residues within a single or among multiple proteins. We use advanced software, XlinkX, to interpret cross-linking data.


H-D Exchange

 

Hydrogen-deuterium exchange mass spectrometry can provide a view of the conformation and dynamics of proteins.