Technology Applied


SP2: Rapid and Automatible Contaminant Removal from Peptide Samples for Proteomic Analyses, Waas M, Pereckas M, Jones Lipinski R, Ashwood, C, Gundry RL, Journal of Proteome Research, 18(4): 1644-1656, 2019. PMID: 30795648

Developed a method for detergent and contaminant removal from proteomics samples.

Are these cardiomyocytes? Protocol development reveals impact of sample preparation on the accuracy of identifying cardiomyocytes by flow cytometry. Waas M, Weerasekera R, Kropp EM, Romero M, Poon E, Boheler KR, Burridge PW, Gundry RL. Sem Cell Reports, 12(2): 395-410, 2019. PMID:30686762.

Developed and applied targeted quantitation assays for two troponin proteins using the Fusion Lumos MS.

Dynamics and Selective Remodeling of the DNA Binding Domains of RPA. Pokhrel N, Caldwell CC, Corless EI, Tillison EA, Tibbs J, Jocic N, Tabei A, Wold MS, Spies M, Antony E., Nature Structural and Molecular Biology, 26, 129-136, 2019. PMID: 30723327

Identification of proteins from gel bands to identify a substitution of 4-azidophenylalanine for threonine.


Quantitative top down mass spectrometry identifies proteoforms differentially released during mechanical stimulation of mouse skin. Moehring F, Waas M, Keppel TR, Rathore D, Cowie AM, Stucky CL, Gundry RL., J Proteome Research, Aug 3;17(8):2635-2648, 2018. PMC6195672

Quantitative top down proteomics to identfiy intact and modified protein proteoforms secreted from mouse skin.

Intact mass analysis of protein-small molecule binding.


Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4. Olp MD, Zhu N, Smith BC., Biochemistry, 56(41): 5485-5495., 2017. PMC5970795