Monoclonal antibody characterization includes a variety of approaches to comprehensively determine the amino acid sequence and modifications.

 

Peptide Mapping

Purified mAb with predicted sequence

Using high mass accuracy peptide-level information and advanced bioinformatics in Byonic, we can assemble peptide sequences onto a mAb framework, including localization and composition of the glycan. 


Subunit Analysis

Purified mAb with predicted sequence

Accurate mass measurements and sequencing of mAb fragments (heavy & light chains) and glycoform analyses.


Intact mAb Analysis

Purified mAb with predicted sequence

Accurate mass analysis of intact mAb.