We are happy to provide input during the grant application planning and submission stages. We provide Investigators with the following:
Letter of support - tailored to your application
Up-to-date Major Instrumentation description
Up-to-date Facilities and Resources description
Dr. Gundry's NIH Biosketch
Preliminary data, when appropriate
Text to describe methods, when appropriate
Budget Justification - tailored to your application, including
Effort for personnel (one of 2 ways)
Collaboration: Included as percent effort for MS Center personnel. Typically, Dr. Gundry is included as a “Significant other contributor” without percent effort. However, this is determined individually as appropriate for each application.
Fee-for-service: Labor costs for the analysis. In this mode, invoicing will include labor and the grant budget will not include percent effort for personnel.
Important Deadlines include:
**One month or more prior to GCO Deadline
Schedule a 15 or 30 min "Grant Assistance Discussion" consultation with Dr. Gundry to discuss the project. With sufficient lead time, we can help you write the research plan sections pertaining to mass spectrometry and provide references and preliminary data, as appropriate.
**7 – 10 days prior to the GCO deadline
Request your grant support documentation.
Considering the large number of grant applications we assist with during each cycle,
it is not possible for us to provide assistance for requests that are made less than 7 days prior to the GCO deadline.
Suggestions for Grant Applications
While it may be tempting to focus exclusively on protein and peptide quantity changes – many biomedical related studies would benefit from measuring protein activity – interactions, modifications, interactions with perturbations in order to advance biology. Don't forget to consider whether it would be worth characterizing a protein in addition to, or rather than, protein abundance.
Avoid proposing to take an "unbiased approach". In reality, everything we do is biased to some degree. It may be biased towards more abundant compounds, more hydrophilic, unmodified vs. modified, etc. Avoid the buzzwords and be specific with regards to what you want to learn.
Mass spectrometry techniques do not measure "protein expression". Rather, we measure peptide or protein abundance, which is the sum of post-transcriptional events, including cleavage, degradation, secretion, shuttling, etc.