One month or more prior to GCO Deadline
Schedule a 15 min "Grant Assistance Discussion" consultation with Dr. Gundry to discuss the project. With sufficient time, we can help you write the research plan sections pertaining to mass spectrometry and provide references and preliminary data, as appropriate.
7 – 10 days prior to the GCO deadline
Request your grant support documentation. We provide the following:
- Preliminary data - tailored to your application - when appropriate
- Letter of support - tailored to your application
- Budget justification - tailored to your application
- Dr. Gundry's NIH Biosketch.
- Updated instrumentation and facilities description pages
Considering the large number of grant applications we assist with during each cycle, it is not possible for us to provide assistance for requests that are made less than 7 days prior to the GCO deadline.
Suggestions for Grant Applications
- While it may be tempting to focus exclusively on protein and peptide quantity changes – many biomedical related studies would benefit from measuring protein activity – interactions, modifications, interactions with perturbations in order to advance biology. Don't forget to consider whether it would be worth characterizing a protein in addition to, or rather than, protein abundance.
- Avoid proposing to take an "unbiased approach". In reality, everything we do is biased to some degree. It may be biased towards more abundant compounds, more hydrophilic, unmodified vs. modified, etc. Avoid the buzzwords and be specific with regards to what you want to learn.
- Mass spectrometry techniques do not measure "protein expression". Rather, we measure peptide or protein abundance, which is the sum of post-transcriptional events, including cleavage, degradation, secretion, shuttling, etc.