Back to All Events

Seminar: When Good Isoforms Go Bad: Mapping Mutation/Modification Crosstalk on KRAS4b in Colorectal Cancer

Neil Kelleher, PhD, Professor, Northwestern University Department of Chemistry

Location: TBRC C2195

Basic science, clinical and translational researchers and staff are invited to attend a special seminar on Thursday, July 12, from 4 - 5 p.m. in TBRC 2195. Dr. Neil Kelleher, the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences, and Medicine in the Weinberg College of Arts and Sciences at Northwestern University, and director of Northwestern Proteomics, will speak about his groundbreaking work to precisely define protein proteoforms in cancer. Specifically, he will discuss the implications of the KRASb isoform in colorectal cancer.

Neil Kelleher's research group is focused on top-down proteomics, chromatin biology, and natural products biosynthesis and discovery. Contributing to both technology development and application of very high-performance mass spectrometry in chemistry and biology, Kelleher is particularly interested in the biosynthesis and discovery of polyketides and non-ribosomally produced peptides. With extensive expertise in complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and natural products research, Kelleher's lab is engaged in the use of intact proteins for efficient detection of their post-translational modifications, with particular interests in chromatin and cancer biology.