Nov
15
4:00 PM16:00

Seminar: When Good Isoforms Go Bad: Mapping Mutation/Modification Crosstalk on KRAS4b in Colorectal Cancer

Neil Kelleher, PhD, Professor, Northwestern University Department of Chemistry

Location: TBRC C2195

Basic science, clinical and translational researchers and staff are invited to attend a special seminar on Thursday, July 12, from 4 - 5 p.m. in TBRC 2195. Dr. Neil Kelleher, the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences, and Medicine in the Weinberg College of Arts and Sciences at Northwestern University, and director of Northwestern Proteomics, will speak about his groundbreaking work to precisely define protein proteoforms in cancer. Specifically, he will discuss the implications of the KRASb isoform in colorectal cancer.

Neil Kelleher's research group is focused on top-down proteomics, chromatin biology, and natural products biosynthesis and discovery. Contributing to both technology development and application of very high-performance mass spectrometry in chemistry and biology, Kelleher is particularly interested in the biosynthesis and discovery of polyketides and non-ribosomally produced peptides. With extensive expertise in complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and natural products research, Kelleher's lab is engaged in the use of intact proteins for efficient detection of their post-translational modifications, with particular interests in chromatin and cancer biology.

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Sep
20
4:00 PM16:00

Seminar: MALDI Imaging: Label-Free Molecular Imaging technology to understand the molecular pathology of tissue & Mass Spectrometry Imaging: Bridging the Gap between Histology and Molecular Biology

Shannon Cornett, PhD, Bruker Daltonics Imaging Business Manager, & Erin Seeley, PhD, New River Labs Chief Technology Officer

Location: TBRC C2195

The Center for Biomedical Mass Spectrometry Research invites basic science, clinical and translational researchers and staff to attend a special seminar at 4:00 pm, Thursday, September 20th, in TBRC 2195. Dr. Shannon Cornett, Imaging Business Manager for Bruker Daltonics, will discuss how MALDI Imaging technology serves as a label-free molecular imaging method to help understand the molecular pathology of tissue. Dr. Erin Seeley, Chief Technology Officer for New River Labs, will discuss how Mass Spectrometry Imaging bridges the gap between histology and molecular biology.

Dr. Cornett spent eight years at Bruker developing applications and platforms for MALDI TOF, before joining Vanderbilt University as an Assistant Professor of Biochemistry in 2002. He worked with Professor Richard Caprioli developing tools and methodologies in imaging mass spectrometry. Dr. Cornett now manages Bruker’s MS imaging business.

Dr. Seeley received a PhD from Purdue in Analytical Chemistry with a focus in Phosphoproteomics. She spent several years working under the direction of Richard Caprioli in the Tissue Imaging Core at Vanderbilt University. Dr. Seeley moved to Protea Biosciences in 2014, managing MALDI imaging service work relating to clinical applications and small molecule quantitation. She co-founded New River Labs this year, which helps develop mass spectrometry imaging-based diagnostic and prognostic assays.

Refreshments will be provided.

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